kulawrKutafin Law ReviewKutafin Law Review2713-05252713-0533MSAL10.17803/2313-5395.2021.1.15.115-128kulawr-120Research ArticleARTICLESGenome-Editing Technologies in Biomedical Research: The Regulatory Conditions for the DevelopmentChaplenkoA. A.

Alexander A. Chaplenko - Cand. Sci., Associate Professor, Department of Organization and Management in the Field of Drugs Circulation, First Moscow State Medical University (Sechenov University).

Bolshaya Pirogovskaya St., 2, build. 4, Moscow, 119435.

a.a.chaplenko@yandex.ruMokhovA. A.

Alexander A. Mokhov - Dr. Sci. (Law), Professor, Head of the Department of Medical Law, Kutafin Moscow State Law University (MSAL).

Sadovaya-Kudrinskaya St., 9, Moscow, 125993.

aamohov@msal.ruYavorskyA. N.

Alexander N. Yavorsky - Dr. Sci. (Medicine), Professor, Chief Researcher, Pushchino State Institute of Natural Science.

Nauki Av., 3, Pushchino, Moscow Region, 142290.

200-31-11@mail.ruFirst Moscow State Medical University (Sechenov University)Russian FederationKutafin Moscow State Law University (MSAL)Russian FederationPushchino State Institute of Natural ScienceRussian Federation20213004202181115128Copyright © Chaplenko A.A., Mokhov A.A., Yavorsky A.N., 20212021Chaplenko A.A., Mokhov A.A., Yavorsky A.N.Chaplenko A.A., Mokhov A.A., Yavorsky A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://kulawr.msal.ru/jour/article/view/120

Significant progress has been made in the development of genetic technologies in recent decades. Currently, high-performance sequencing and, most importantly, genome editing technologies are widely used and available for laboratories in Russia. Existing technologies are not without drawbacks that significantly hinder further development, in addition, all the necessary reagents and materials, as well as equipment, are produced exclusively abroad. The review highlights the international experience of using genome editing technologies for the treatment and prevention of genetic diseases, vector-borne and viral infections, it offers recommendations for the development of this area in the Russian Federation. Attention is drawn to the legal and ethical regulation, mainly at the level of basic principles. The conclusion is formulated on the need for accelerated adaptation of basic ethical and legal principles for genome editing activities in scientific biomedical activities.

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The authors declare that there are no conflicts of interest present.